There are a few possible solutions here. Check to make sure your document doesn’t contain macros. If it does, you’ll need to save the file as a .pdf before you can upload it into e-signing.
Another possibility is that the document is password protected. Remove the password restrictions within your security settings and you should be ok.
Finally, there is always a chance your document has been corrupted. If that’s the case, the first thing to do is save the document as a new .pdf and repeat the upload process.
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